A Murine Model of Alcoholic Cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Alcoholic cardiomyopathy: a review.
Alcohol abuse can cause cardiomyopathy indistinguishable from other types of dilated nonischemic cardiomyopathy. Most heavy drinkers remain asymptomatic in the earlier stages of disease progression, and many never develop the familiar clinical manifestations that typify heart failure. We review the current thinking on the pathophysiology, clinical characteristics, and treatments available for a...
متن کاملReversibility of alcoholic cardiomyopathy.
A patient with alcoholic cardiomyopathy is described in whom cardiovascular function capacity and radiological heart size fluctuated widely with periods of heavy drinking and abstinence. On two occasions, cessation of drinking resulted in clinical recovery from severe degrees of congestive failure and in complete reversal of cardiac enlargement. Echocardiographic follow-up showed, however, that...
متن کاملEffect of Alcohol on Heart: Case Presentation of Two Alcoholic Patients with Alcoholic Cardiomyopathy
Background: Alcohol consumption has multiple side effects on heart which can be divided to six subgroups: Heavy alcohol drinkers (80 g/day alcohol consumption) are most susceptible to cardiac complications. The aim of this study was to review alcohol side effects on heart and two present two alcoholic patients with alcoholic cardiomyopathy. Case report: Case A: A 52 year-old man presented with ...
متن کاملThe electrocardiogram of alcoholic cardiomyopathy.
The harmful effects of excessive alcohol consumption on the liver have long been recognized. A corresponding injury to the heart has not received the same attention except as part of the syndrome of beriberi attributable to thiamine deficiency. Not infrequently, however, when some form of heart disease is suspected on account of symptoms like breathlessness, palpitation, or chest pain, and when...
متن کاملA murine model of isolated cardiac steatosis leads to cardiomyopathy.
Lipid accumulation in the heart is associated with obesity and diabetes mellitus and may play an important role in the pathogenesis of heart failure seen in this patient population. Stored triglycerides are synthesized by the enzyme diacylglycerol acyl transferase (DGAT). We hypothesized that forced expression of DGAT1 in the cardiac myocyte would result in increased lipid accumulation and hear...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2005
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)62975-6